Navigate the Landscape of EOE
Clinical trials, publications, and treatment insights curated by AI agents to accelerate your research.
What is Eosinophilic Esophagitis?
Click an organ to explore its impact
Hover or click an organ to explore
Eosinophilic Esophagitis (EOE) is a chronic, immune-mediated disease in which eosinophils, white blood cells that normally help fight parasitic infections, infiltrate the esophageal lining in abnormally high numbers. This persistent buildup triggers ongoing inflammation that damages tissue over time, leading to fibrosis, stricture formation, and a progressively narrowed esophagus that makes swallowing increasingly difficult.
Patients commonly experience dysphagia, food impaction, chest pain unrelated to heart disease, and persistent heartburn that does not respond to standard acid-reflux medications. In children, symptoms often present as feeding difficulties, vomiting, and failure to thrive. EOE is strongly associated with atopic conditions, and roughly half of all patients also live with asthma, eczema, allergic rhinitis, or IgE-mediated food allergies. First recognized as a distinct diagnosis in the early 1990s, its reported incidence has risen sharply, driven by improved awareness, standardized diagnostic criteria, and a genuine increase in allergic disease worldwide.
About This Project
Hi, I'm Jason Ungheanu. This project is personal. I was diagnosed with eosinophilic esophagitis in 2017, and since then I've lived with the daily realities of managing a chronic condition that most people have never heard of. The difficulty swallowing, the dietary restrictions, the endoscopies, the trial-and-error of treatments. It's a condition that forces you to become your own advocate and, inevitably, your own researcher.
My background is in data and research, and I've spent my career working at the intersection of technology and complex problem-solving. When I started digging into EOE literature, I realized how scattered and inaccessible the information was, especially for patients trying to understand their own condition. That frustration became the motivation for EOE Atlas: a platform that applies AI-powered research tools to surface the latest PubMed publications, track active clinical trials, and organize findings in a way that's actually useful.
This sits at the intersection of clinical immunology and translational research, built by someone who genuinely needs it to exist. Whether you're a researcher, a clinician managing EOE patients, or someone personally affected by the disease, you're invited to explore the tools and data collected here. The goal is simple: make the best available evidence easier to find, understand, and act on.